Inkretinkompendiet

Referenser

Ahmad, S.R., and J. Swann. 2008. 'Exenatide and rare adverse events', N. Engl. J. Med, 358: 1970-71.
Ahren, B. 2009. ’Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin--diabetes control and potential adverse events’, Best. Pract. Res. Clin. Endocrinol. Metab, 23: 487-98.
———. 2011a. ’The dynamic incretin adaptation and type 2 diabetes’, J. Clin. Endocrinol. Metab, 96: 620-22.
———. 2011b. ’GLP-1 for type 2 diabetes’, Exp. Cell Res, 317: 1239-45.
———. 2014. ’The neuro-incretin concept’, Regul Pept, 194-195: 3-5.
———. 2015. ’Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes’, Diabetes, 64: 715-7.

Ahren, B., R.D. Carr, and C.F. Deacon. 2010. ’Incretin hormone secretion over the day’, Vitam. Horm, 84: 203-20.

Ahren, B., E. Simonsson, H. Larsson, M. Landin-Olsson, H. Torgeirsson, P.A. Jansson, M. Sandqvist, P. Bavenholm, S. Efendic, J.W. Eriksson, S. Dickinson, and D. Holmes. 2002. ’Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes’, Diabetes Care, 25: 869-75.

Amori, R.E., J. Lau, and A.G. Pittas. 2007. ’Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis’, JAMA, 298: 194-206.

Arakawa, M., T. Mita, K. Azuma, C. Ebato, H. Goto, T. Nomiyama, Y. Fujitani, T. Hirose, R. Kawamori, and H. Watada. 2010. ’Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4’, Diabetes, 59: 1030-37.

Azoulay, L., K. B. Filion, R. W. Platt, M. Dahl, C. R. Dormuth, K. K. Clemens, M. Durand, D. N. Juurlink, L. E. Targownik, T. C. Turin, J. M. Paterson, P. Ernst, and Investigators Canadian Network for Observational Drug Effect Studies. 2016. 'Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study', BMJ, 352: i581.

Bagger, J.I., F.K. Knop, A. Lund, H. Vestergaard, J.J. Holst, and T. Vilsboll. 2011. ’Impaired regulation of the incretin effect in patients with type 2 diabetes’, J. Clin. Endocrinol. Metab, 96: 737-45.

Balkan, B., and X. Li. 2000. ’Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms’, Am. J. Physiol Regul. Integr. Comp Physiol, 279: R1449-R54.

Ban, K., M.H. Noyan-Ashraf, J. Hoefer, S.S. Bolz, D.J. Drucker, and M. Husain. 2008. ’Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways’, Circulation, 117: 2340-50.

Barnett, A.H., J. Burger, D. Johns, R. Brodows, D.M. Kendall, A. Roberts, and M.E. Trautmann. 2007. ’Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial’, Clin. Ther, 29: 2333-48.

Barragan, J.M., R.E. Rodriguez, J. Eng, and E. Blazquez. 1996. ’Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats’, Regul. Pept, 67: 63-68.

Basu, A., N. Charkoudian, W. Schrage, R.A. Rizza, R. Basu, and M.J. Joyner. 2007. ’Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride’, Am. J. Physiol Endocrinol. Metab, 293: E1289-E95.

Bergenstal, R.M., C. Wysham, L. MacConell, J. Malloy, B. Walsh, P. Yan, K. Wilhelm, J. Malone, and L.E. Porter. 2010. ’Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial’, The Lancet. 376 (9739) ()(pp 431-439), 2010. Date of Publication: August 2010: 431-39.

Best, J.H., B.J. Hoogwerf, W.H. Herman, E.M. Pelletier, D.B. Smith, M. Wenten, and M.A. Hussein. 2011. ’Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose- lowering therapies: a retrospective analysis of the LifeLink database’, Diabetes Care, 34: 90-95.

Bhashyam, S., A.V. Fields, B. Patterson, J.M. Testani, L. Chen, Y.T. Shen, and R.P. Shannon. 2010. ’Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy’, Circ. Heart Fail, 3: 512-21.

Blase, E., K. Taylor, H.Y. Gao, M. Wintle, and M. Fineman. 2005. ’Pharmacokinetics of an oral drug (acetaminophen) administered at various times in relation to subcutaneous injection of exenatide (exendin-4) in healthy subjects’, J. Clin. Pharmacol, 45: 570-77.

Blevins, T., J. Han, D. Nicewarner, S. Chen, J.H. Oliveira, and S. Aronoff. 2010. ’Exenatide is non-inferior to insulin in reducing HbA1c: an integrated analysis of 1423 patients with type 2 diabetes’, Postgrad. Med, 122: 118-28.
Blevins, T., J. Pullman, J. Malloy, P. Yan, K. Taylor, C. Schulteis, M. Trautmann, and L. Porter. 2011. ’DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes’, J. Clin. Endocrinol. Metab, 96: 1301-10.

Blonde, L., J. Jendle, J. Gross, V. Woo, H. Jiang, J. L. Fahrbach, and Z. Milicevic. 2015. ’Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study’, Lancet, 385: 2057-66.

Blonde, L., and D. Russell-Jones. 2009. ’The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies’, Diabetes Obes. Metab, 11 Suppl 3: 26-34.

Bose, A.K., M.M. Mocanu, R.D. Carr, C.L. Brand, and D.M. Yellon. 2005. ’Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury’, Diabetes, 54: 146-51.

Buchwald, H., Y. Avidor, E. Braunwald, M.D. Jensen, W. Pories, K. Fahrbach, and K. Schoelles. 2004. ’Bariatric surgery: a systematic review and meta-analysis’, JAMA, 292: 1724-37.

Bunck, M.C., A. Corner, B. Eliasson, R.J. Heine, R.M. Shaginian, M.R. Taskinen, U. Smith, H. Yki-Jarvinen, and M. Diamant. 2011. ’Effects of exenatide on measures of beta-cell function after 3 years in metformin-treated patients with type 2 diabetes’, Diabetes Care, 34: 2041-47.

Bunck, M.C., B. Eliasson, A. Corner, R.J. Heine, R.M. Shaginian, M.R. Taskinen, H. Yki-Jarvinen, U. Smith, and M. Diamant. 2011. ’Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes’, Diabetes Obes. Metab, 13: 374-77.

Buse, J. B., M. Nauck, T. Forst, W. H. Sheu, S. K. Shenouda, C. R. Heilmann, B. J. Hoogwerf, A. Gao, M. K. Boardman, M. Fineman, L. Porter, and G. Schernthaner. 2013. ’Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study’, Lancet, 381: 117-24.

Buse, J.B., D.J. Drucker, K.L. Taylor, T. Kim, B. Walsh, H. Hu, K. Wilhelm, M. Trautmann, L.Z. Shen, and L.E. Porter. 2010. ’DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks’, Diabetes Care, 33: 1255-61.

Buse, J.B., J. Rosenstock, G. Sesti, W.E. Schmidt, E. Montanya, J.H. Brett, M. Zychma, and L. Blonde. 2009. ’Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)’, Lancet, 374: 39-47.

Butler, A. E., M. Campbell-Thompson, T. Gurlo, D. W. Dawson, M. Atkinson, and P. C. Butler. 2013. 'Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors', Diabetes, 62: 2595-604.

Ceriello, A., K. Esposito, R. Testa, A.R. Bonfigli, M. Marra, and D. Giugliano. 2011. ’The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an ”endothelial resistance” to glucagon-like peptide 1 in diabetes’, Diabetes Care, 34: 697-702.

Chacra, A.R., G.H. Tan, A. Apanovitch, S. Ravichandran, J. List, and R. Chen. 2009. ’Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial’, Int. J. Clin. Pract, 63: 1395-406.

Chilton, R., J. Wyatt, S. Nandish, R. Oliveros, and M. Lujan. 2011. ’Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagonlike peptide-1-based therapies’, Am. J. Med, 124: S35-S53.

Costante, G., D. Meringolo, C. Durante, D. Bianchi, M. Nocera, S. Tumino, U. Crocetti, M. Attard, M. Maranghi, M. Torlontano, and S. Filetti. 2007. 'Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules', J. Clin. Endocrinol. Metab, 92: 450-55.

Courreges, J.P., T. Vilsboll, M. Zdravkovic, T. Le-Thi, T. Krarup, O. Schmitz, R. Verhoeven, I. Buganova, and S. Madsbad. 2008. ’Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes’, Diabet. Med, 25: 1129-31.

Creutzfeldt, W. 2005. ’The [pre-] history of the incretin concept’, Regul. Pept, 128: 87-91.

Davies, M. J., R. Bergenstal, B. Bode, R. F. Kushner, A. Lewin, T. V. Skjoth, A. H. Andreasen, C. B. Jensen, R. A. DeFronzo, and N. N. Study Group. 2015. ’Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial’, JAMA, 314: 687-99.

de Heer, J., and J.J. Holst. 2007. ’Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1’, Diabetes, 56: 438-43.

Deacon, C.F. 2005. ’What do we know about the secretion and degradation of incretin hormones?’, Regul. Pept, 128: 117-24.
DeFronzo, R. A., A. H. Stonehouse, J. Han, and M. E. Wintle. 2010. ’Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials’, Diabet Med, 27: 309-17.

DeFronzo, R.A., T. Okerson, P. Viswanathan, X. Guan, J.H. Holcombe, and L. MacConell. 2008. ’Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study’, Curr. Med. Res. Opin, 24: 2943-52.

DeFronzo, R.A., R.E. Ratner, J. Han, D.D. Kim, M.S. Fineman, and A.D. Baron. 2005. ’Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes’, Diabetes Care, 28: 1092-100.

Degn, K.B., C.B. Juhl, J. Sturis, G. Jakobsen, B. Brock, V. Chandramouli, J. Rungby, B.R. Landau, and O. Schmitz. 2004. ’One week’s treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes’, Diabetes, 53: 1187-94.

Denker, P. S., and P. E. Dimarco. 2006. 'Exenatide (exendin-4)-induced pancreatitis: a case report', Diabetes Care, 29: 471.

Diamant, M., Gaal L. Van, S. Stranks, J. Northrup, D. Cao, K. Taylor, and M. Trautmann. 2010. ’Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial’, The Lancet. 375 (9733) ()(pp 2234-2243), 2010. Date of Publication: 20100626/0702: 2234-43.

Dore, D.D., G.L. Bloomgren, M. Wenten, C. Hoffman, C.R. Clifford, S.G. Quinn, D.K. Braun, R.A. Noel, and J.D. Seeger. 2011. 'A cohort study of acute pancreatitis in relation to exenatide use', Diabetes Obes. Metab, 13: 559-66.

Dore, D.D., J.D. Seeger, and Chan K. Arnold. 2009. 'Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide', Curr. Med. Res. Opin, 25: 1019-27.

Doyle, M.E., and J.M. Egan. 2007. ’Mechanisms of action of glucagon-like peptide 1 in the pancreas’, Pharmacol. Ther, 113: 546-93.

Drucker, D.J., and M.A. Nauck. 2006. ’The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes’, Lancet, 368: 1696-705.

Dungan, K. M., S. T. Povedano, T. Forst, J. G. Gonzalez, C. Atisso, W. Sealls, and J. L. Fahrbach. 2014. ’Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial’, Lancet, 384: 1349-57.

Edholm, T., M. Degerblad, P. Gryback, L. Hilsted, J.J. Holst, H. Jacobsson, S. Efendic, P.T. Schmidt, and P.M. Hellstrom. 2010. ’Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis’, Neurogastroenterol. Motil, 22: 1191-200, e315.

Egan, A. G., E. Blind, K. Dunder, P. A. de Graeff, B. T. Hummer, T. Bourcier, and C. Rosebraugh. 2014. 'Pancreatic safety of incretin-based drugs--FDA and EMA assessment', N Engl J Med, 370: 794-7.

Elashoff, M., A. V. Matveyenko, B. Gier, R. Elashoff, and P. C. Butler. 2011. 'Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies', Gastroenterology, 141: 150-6.

EMA. 2012. "Lyxumia European Public Assessment Report (EPAR)." In.

Engel, S. S., G. T. Golm, and B. Lauring. 2013. 'Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604', Diabetes, 62: e18.

Erdogdu, O., D. Nathanson, A. Sjoholm, T. Nystrom, and Q. Zhang. 2010. ’Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor’, Mol. Cell Endocrinol, 325: 26-35.

Faillie, J. L., L. Azoulay, V. Patenaude, D. Hillaire-Buys, and S. Suissa. 2014. 'Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study', BMJ, 348: g2780.

Fakhoury, W.K., C. Lereun, and D. Wright. 2010. ’A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes’, Pharmacology, 86: 44-57.

Ferdinand, K. C., F. T. Botros, C. M. Atisso, and P. T. Sager. 2016. ’Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events’, Cardiovasc Diabetol, 15: 38.

Filion, K. B., L. Azoulay, R. W. Platt, M. Dahl, C. R. Dormuth, K. K. Clemens, N. Hu, J. M. Paterson, L. Targownik, T. C. Turin, J. A. Udell, P. Ernst, and Cnodes Investigators. 2016. 'A Multicenter Observational Study of Incretin-based Drugs and Heart Failure', N Engl J Med, 374: 1145-54.

Fineman, M. S., K. F. Mace, M. Diamant, T. Darsow, B. B. Cirincione, T. K. Booker Porter, L. A. Kinninger, and M. E. Trautmann. 2012. 'Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment', Diabetes Obes Metab, 14: 546-54.

Gable, D.R., S.J. Hurel, and S.E. Humphries. 2006. ’Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease’, Atherosclerosis, 188: 231-44.

Gaede, P., P. Vedel, N. Larsen, G.V. Jensen, H.H. Parving, and O. Pedersen. 2003. ’Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes’, N. Engl. J. Med, 348: 383-93.

Garber, A., R. Henry, R. Ratner, P.A. Garcia-Hernandez, H. Rodriguez-Pattzi, I. Olvera-Alvarez, P.M. Hale, M. Zdravkovic, and B. Bode. 2009. ’Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial’, Lancet, 373: 473-81.

Giorgino, F., M. Benroubi, J. H. Sun, A. G. Zimmermann, and V. Pechtner. 2015. ’Efficacy and Safety of Once-Weekly Dulaglutide Versus Insulin Glargine in Patients With Type 2 Diabetes on Metformin and Glimepiride (AWARD-2)’, Diabetes Care, 38: 2241-9.

Gokhale M, Buse JB, Gray CL, Pate V, Marquis MA, Stürmer T. 2014. Dipeptidyl-peptidase-4 inhibitors and pancreatic cancer: a cohort study. Diabetes Obes Metab. 16(12):1247-56.

Golpon, H.A., A. Puechner, T. Welte, P.V. Wichert, and C.O. Feddersen. 2001. ’Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat’, Regul. Pept, 102: 81-86.

Goto, H., T. Nomiyama, T. Mita, E. Yasunari, K. Azuma, K. Komiya, M. Arakawa, W.L. Jin, A. Kanazawa, R. Kawamori, Y. Fujitani, T. Hirose, and H. Watada. 2011. ’Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury’, Biochem. Biophys. Res. Commun, 405: 79-84.

Green, J. B., M. A. Bethel, P. W. Armstrong, J. B. Buse, S. S. Engel, J. Garg, R. Josse, K. D. Kaufman, J. Koglin, S. Korn, J. M. Lachin, D. K. McGuire, M. J. Pencina, E. Standl, P. P. Stein, S. Suryawanshi, F. Van de Werf, E. D. Peterson, R. R. Holman, and Tecos Study Group. 2015. ’Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes’, N Engl J Med, 373: 232-42.

Gros, R., X. You, L.L. Baggio, M.G. Kabir, A.M. Sadi, I.N. Mungrue, T.G. Parker, Q. Huang, D.J. Drucker, and M. Husain. 2003. ’Cardiac function in mice lacking the glucagon-like peptide-1 receptor’, Endocrinology, 144: 2242-52.

Gutniak, M., C. Orskov, J.J. Holst, B. Ahren, and S. Efendic. 1992. ’Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus’, N. Engl. J. Med, 326: 1316-22.

Haffner, S.M., S. Lehto, T. Ronnemaa, K. Pyorala, and M. Laakso. 1998. ’Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction’, N. Engl. J. Med, 339: 229-34.

Halbirk, M., H. Norrelund, N. Moller, J.J. Holst, O. Schmitz, R. Nielsen, J.E. Nielsen-Kudsk, S.S. Nielsen, T.T. Nielsen, H. Eiskjaer, H.E. Botker, and H. Wiggers. 2010. ’Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure’, Am. J. Physiol Heart Circ. Physiol, 298: H1096-H102.

Hattori, Y., T. Jojima, A. Tomizawa, H. Satoh, S. Hattori, K. Kasai, and T. Hayashi. 2010. ’A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells’, Diabetologia, 53: 2256-63.

Hayes, M.R., B.C. De Jonghe, and S.E. Kanoski. 2010. ’Role of the glucagon-like-peptide-1 receptor in the control of energy balance’, Physiol Behav, 100: 503-10.

Heine, R. J., H. Fu, D. M. Kendall, and D. E. Moller. 2013. 'Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604', Diabetes, 62: e16-7.

Holman, R. R., M. A. Bethel, J. George, H. Sourij, Z. Doran, J. Keenan, N. S. Khurmi, R. J. Mentz, A. Oulhaj, J. B. Buse, J. C. Chan, N. Iqbal, S. Kundu, A. P. Maggioni, S. P. Marso, P. Ohman, M. J. Pencina, N. Poulter, L. E. Porter, A. Ramachandran, B. Zinman, and A. F. Hernandez. 2016. ’Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial’, Am Heart J, 174: 103-10.

Holman, R.R., S.K. Paul, M.A. Bethel, D.R. Matthews, and H.A. Neil. 2008. ’10-year follow-up of intensive glucose control in type 2 diabetes’, N. Engl. J. Med, 359: 1577-89.

Holst, J.J., C.F. Deacon, T. Vilsboll, T. Krarup, and S. Madsbad. 2008. ’Glucagon-like peptide-1, glucose homeostasis and diabetes’, Trends Mol. Med, 14: 161-68.
Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK(Eds). 2009. "SEER Cancer Statistics Review, 1975–2006." In. National Cancer Institute. Available from http://seer.cancer.gov/csr/1975_2006/: National Cancer Institute.

Horton, E.S., C. Silberman, K.L. Davis, and R. Berria. 2010. ’Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database’, Diabetes Care, 33: 1759-65.

Ishibashi, Y., T. Matsui, M. Takeuchi, and S. Yamagishi. 2010. ’Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression’, Biochem. Biophys. Res. Commun, 391: 1405-08.

Jendle, J., M.A. Nauck, D.R. Matthews, A. Frid, K. Hermansen, M. During, M. Zdravkovic, B.J. Strauss, and A.J. Garber. 2009. ’Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue’, Diabetes Obes. Metab, 11: 1163-72.

Jensen, T. M., K. Saha, and W. M. Steinberg. 2015. 'Is there a link between liraglutide and pancreatitis? A post hoc review of pooled and patient-level data from completed liraglutide type 2 diabetes clinical trials', Diabetes Care, 38: 1058-66.

Jimenez-Solem, E., M.H. Rasmussen, M. Christensen, and F.K. Knop. 2010. ’Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes’, Curr. Opin. Mol. Ther, 12: 790-97.

Juntti-Berggren, L., J. Pigon, F. Karpe, A. Hamsten, M. Gutniak, L. Vignati, and S. Efendic. 1996. ’The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients’, Diabetes Care, 19: 1200-06.

Kapitza, C., T. Forst, H. V. Coester, F. Poitiers, P. Ruus, and A. Hincelin-Mery. 2013. ’Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin’, Diabetes Obes Metab, 15: 642-9.

Karra, E., A. Yousseif, and R.L. Batterham. 2010. ’Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery’, Trends Endocrinol. Metab, 21: 337-44.

Kayaniyil, S., G. Lozano-Ortega, H. A. Bennett, K. Johnsson, A. Shaunik, S. Grandy, and B. Kartman. 2016. 'A Network Meta-analysis Comparing Exenatide Once Weekly with Other GLP-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus', Diabetes Ther, 7: 27-43.

Kielgast, U., J. J. Holst, and S. Madsbad. 2009. ’Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists’, Curr Diabetes Rev, 5: 266-75.

Klonoff, D.C., J.B. Buse, L.L. Nielsen, X. Guan, C.L. Bowlus, J.H. Holcombe, M.E. Wintle, and D.G. Maggs. 2008. ’Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years’, Curr. Med. Res. Opin, 24: 275-86.

Koska, J., E.A. Schwartz, M.P. Mullin, D.C. Schwenke, and P.D. Reaven. 2010. ’Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes’, Diabetes Care, 33: 1028-30.

Laferrere, B., S. Heshka, K. Wang, Y. Khan, J. McGinty, J. Teixeira, A.B. Hart, and B. Olivan. 2007. ’Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes’, Diabetes Care, 30: 1709-16.

Laferrere, B., J. Teixeira, J. McGinty, H. Tran, J.R. Egger, A. Colarusso, B. Kovack, B. Bawa, N. Koshy, H. Lee, K. Yapp, and B. Olivan. 2008. ’Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes’, J. Clin. Endocrinol. Metab, 93: 2479-85.

Lai, S. W., C. H. Muo, K. F. Liao, F. C. Sung, and P. C. Chen. 2011. 'Risk of acute pancreatitis in type 2 diabetes and risk reduction on anti-diabetic drugs: a population-based cohort study in Taiwan', Am J Gastroenterol, 106: 1697-704.

Liu, H., Y. Hu, R.W. Simpson, and A.E. Dear. 2008. ’Glucagon-like peptide-1 attenuates tumour necrosis factor-alpha-mediated induction of plasminogen [corrected] activator inhibitor-1 expression’, J. Endocrinol, 196: 57-65.

Lonborg, J., N. Vejlstrup, H. Kelbaek, H. E. Botker, W. Y. Kim, A. B. Mathiasen, E. Jorgensen, S. Helqvist, K. Saunamaki, P. Clemmensen, L. Holmvang, L. Thuesen, L. R. Krusell, J. S. Jensen, L. Kober, M. Treiman, J. J. Holst, and T. Engstrom. 2012. ’Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction’, Eur Heart J, 33: 1491-9.

Lovshin, J.A., and D.J. Drucker. 2009. ’Incretin-based therapies for type 2 diabetes mellitus’, Nat. Rev. Endocrinol, 5: 262-69.

Lunati, M. E., V. Grancini, C. Colombo, E. Palmieri, V. Resi, M. Perrino, E. Orsi, and L. Fugazzola. 2016. 'Basal and stimulated calcitonin levels in patients with type 2 diabetes did not change during 1year of Liraglutide treatment', Metabolism, 65: 1-6.
Madsbad, S. 2016. 'Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists', Diabetes Obes Metab, 18: 317-32.

Madsbad, S., U. Kielgast, M. Asmar, C. Deacon, S.S. Torekov, and J.J. Holst. 2011. ’An overview of once-weekly GLP-1 receptor agonists - available efficacy and safety data and perspectives for the future’, Diabetes Obes. Metab.

Malin, S. K., and S. R. Kashyap. 2015. ’Differences in Weight Loss and Gut Hormones: Rouen-Y Gastric Bypass and Sleeve Gastrectomy Surgery’, Curr Obes Rep, 4: 279-86.

Mari, A., W.M. Sallas, Y.L. He, C. Watson, M. Ligueros-Saylan, B.E. Dunning, C.F. Deacon, J.J. Holst, and J.E. Foley. 2005. ’Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes’, J. Clin. Endocrinol. Metab, 90: 4888-94.

Marre, M., J. Shaw, M. Brandle, W.M. Bebakar, N.A. Kamaruddin, J. Strand, M. Zdravkovic, T.D. Le Thi, and S. Colagiuri. 2009. ’Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)’, Diabet. Med, 26: 268-78.

Marso, S.P., G.H. Daniels, K. Brown-Frandsen, P. Kristensen, J.F.E. Mann, M.A. Nauck, S.E. Nissen, S. Pocock, N.R. Poulter, L.S. Ravn, W.M. Steinberg, M. Stockner, B. Zinman, R.M. Bergenstal, J.B. Buse, for the LEADER Steering Committee on behalf of the LEADER Trial Investigators. 2016. ´Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes´, N Engl J Med, 375: 311-22.

Marso, S. P., N. R. Poulter, S. E. Nissen, M. A. Nauck, B. Zinman, G. H. Daniels, S. Pocock, W. M. Steinberg, R. M. Bergenstal, J. F. Mann, L. S. Ravn, K. B. Frandsen, A. C. Moses, and J. B. Buse. 2013. ’Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial’, Am Heart J, 166: 823-30 e5.

Marso, S.P., S.C. Bain, A. Consoli, F.G. Eliaschewitz, E. Jódar, L.A. Leiter, I. Lingvay, J. Rosenstock, J. Seufert, M.L. Warren, V. Woo, O. Hansen, A.G. Holst, J. Pettersson and T. Vilsboll, for the SUSTAIN-6 Investigators. 2016. ´Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes´, N Engl J Med, epub.

Marx, N., J. Rosenstock, S. E. Kahn, B. Zinman, J. J. Kastelein, J. M. Lachin, M. A. Espeland, E. Bluhmki, M. Mattheus, B. Ryckaert, S. Patel, O. E. Johansen, and H. J. Woerle. 2015. ’Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA(R))’, Diab Vasc Dis Res, 12: 164-74.

Matikainen, N., S. Manttari, A. Schweizer, A. Ulvestad, D. Mills, B.E. Dunning, J.E. Foley, and M.R. Taskinen. 2006. ’Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes’, Diabetologia, 49: 2049-57.

Meier, J. J., J. Rosenstock, A. Hincelin-Mery, C. Roy-Duval, A. Delfolie, H. V. Coester, B. A. Menge, T. Forst, and C. Kapitza. 2015. ’Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial’, Diabetes Care, 38: 1263-73.

Meier, J.J., A. Gethmann, O. Gotze, B. Gallwitz, J.J. Holst, W.E. Schmidt, and M.A. Nauck. 2006. ’Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans’, Diabetologia, 49: 452-58.

Nathanson, D., B. Ullman, U. Lofstrom, A. Hedman, M. Frick, A. Sjoholm, and T. Nystrom. 2012. ’Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety’, Diabetologia, 55: 926-35.

Nauck, M. A., and N. Friedrich. 2013. 'Do GLP-1-based therapies increase cancer risk?', Diabetes Care, 36 Suppl 2: S245-52.

Nauck, M., A. Frid, K. Hermansen, N.S. Shah, T. Tankova, I.H. Mitha, M. Zdravkovic, M. During, and D.R. Matthews. 2009. ’Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study’, Diabetes Care, 32: 84-90.

Nauck, M., F. Stockmann, R. Ebert, and W. Creutzfeldt. 1986. ’Reduced incretin effect in type 2 (non-insulin-dependent) diabetes’, Diabetologia, 29: 46-52.

Nauck, M.A., G. Meininger, D. Sheng, L. Terranella, and P.P. Stein. 2007. ’Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial’, Diabetes Obes. Metab, 9: 194-205.

Nauck, M.A., I. Vardarli, C.F. Deacon, J.J. Holst, and J.J. Meier. 2011. ’Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?’, Diabetologia, 54: 10-18.

Nauck, M., M. Rizzo, A. Johnson, H. Bosch-Traberg, J. Madsen, and B. Cariou. 2016. 'Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial', Diabetes Care, 39: 1501-9.
Nikolaidis, L.A., D. Elahi, T. Hentosz, A. Doverspike, R. Huerbin, L. Zourelias, C. Stolarski, Y.T. Shen, and R.P. Shannon. 2004. ’Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy’, Circulation, 110: 955-61.

Nikolaidis, L.A., D. Elahi, Y.T. Shen, and R.P. Shannon. 2005. ’Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy’, Am. J. Physiol Heart Circ. Physiol, 289: H2401-H08.

Nikolaidis, L.A., S. Mankad, G.G. Sokos, G. Miske, A. Shah, D. Elahi, and R.P. Shannon. 2004. ’Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion’, Circulation, 109: 962-65.

Noel, R.A., D.K. Braun, R.E. Patterson, and G.L. Bloomgren. 2009. 'Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study', Diabetes Care, 32: 834-38.

Novo, Nordisk. 2009. "FDA Advisory Committee Nonclinical Briefing Document." In. FDA. Noyan-Ashraf, M.H., M.A. Momen, K. Ban, A.M. Sadi, Y.Q. Zhou, A.M. Riazi, L.L. Baggio, R.M. Henkelman, M. Husain, and D.J. Drucker. 2009. ’GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice’, Diabetes, 58: 975-83.

Nystrom, T. 2008. ’The potential beneficial role of glucagon-like peptide-1 in endothelial dysfunction and heart failure associated with insulin resistance’, Horm. Metab Res, 40: 593-606.

Nystrom, T., A.T. Gonon, A. Sjoholm, and J. Pernow. 2005. ’Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism’, Regul. Pept, 125: 173-77.

Nystrom, T., M.K. Gutniak, Q. Zhang, F. Zhang, J.J. Holst, B. Ahren, and A. Sjoholm. 2004. ’Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease’, Am. J. Physiol Endocrinol. Metab, 287: E1209-E15.

Perfetti, R., and H. Hui. 2004. ’The role of GLP-1 in the life and death of pancreatic beta cells’, Horm. Metab Res, 36: 804-10.

Peters, A. 2010. ’Incretin-based therapies: review of current clinical trial data’, Am. J. Med, 123: S28-S37.

Pfeffer, M. A., B. Claggett, R. Diaz, K. Dickstein, H. C. Gerstein, L. V. Kober, F. C. Lawson, L. Ping, X. Wei, E. F. Lewis, A. P. Maggioni, J. J. McMurray, J. L. Probstfield, M. C. Riddle, S. D. Solomon, J. C. Tardif, and Elixa Investigators. 2015. ’Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome’, N Engl J Med, 373: 2247-57.

Phillips, L. K., and J. B. Prins. 2011. ’Update on incretin hormones’, Ann N Y Acad Sci, 1243: E55-74.

Pi-Sunyer, X., A. Astrup, K. Fujioka, F. Greenway, A. Halpern, M. Krempf, D. C. Lau, C. W. le Roux, R. Violante Ortiz, C. B. Jensen, J. P. Wilding, Scale Obesity, and N. N. Study Group Prediabetes. 2015. ’A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management’, N Engl J Med, 373: 11-22.

Prasad-Reddy, L., and D. Isaacs. 2015. ’A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond’, Drugs Context, 4: 212283.

Pratley, R. E., M. A. Nauck, A. H. Barnett, M. N. Feinglos, F. Ovalle, I. Harman-Boehm, J. Ye, R. Scott, S. Johnson, M. Stewart, J. Rosenstock, and Harmony study group. 2014. ’Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study’, Lancet Diabetes Endocrinol, 2: 289-97.

Pratley, R.E., M. Nauck, T. Bailey, E. Montanya, R. Cuddihy, S. Filetti, A.B. Thomsen, R.E. Sondergaard, and M. Davies. 2010. 'Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial', Lancet, 375: 1447-56.

Qin, X., H. Shen, M. Liu, Q. Yang, S. Zheng, M. Sabo, D.A. D’Alessio, and P. Tso. 2005. ’GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats’, Am. J. Physiol Gastrointest. Liver Physiol, 288: G943-G49.

Ratner, R., J. Han, D. Nicewarner, I. Yushmanova, B.J. Hoogwerf, and L. Shen. 2011. ’Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes’, Cardiovasc. Diabetol, 10: 22.

Raz I, Bhatt DL, Hirshberg B, Mosenzon O, Scirica BM, Umez-Eronini A, Im K,Stahre C, Buskila A, Iqbal N, Greenberger N, Lerch MM. 2014. Incidence of pancreatitis and pancreatic cancer in a randomized controlled multicenter trial (SAVOR-TIMI 53) of the dipeptidyl peptidase-4 inhibitor saxagliptin. Diabetes Care. 2014 Sep;37(9):2435-41.

Read, P.A., F.Z. Khan, P.M. Heck, S.P. Hoole, and D.P. Dutka. 2010. ’DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease’, Circ. Cardiovasc. Imaging, 3: 195-201.
Rehman, M. B., B. V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain, H. Vaillant-Roussel, F. Gueyffier, J. L. Faillie, M. C. Perault-Pochat, C. Cornu, and R. Boussageon. 2016. 'Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials', Diabetes Metab. ePub.

Roshanov PS, Dennis BB. 2015. Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials. Diabetes Res Clin Pract. 110(3):e13-7.

Rosenstock, J., D. Raccah, L. Koranyi, L. Maffei, G. Boka, P. Miossec, and J. E. Gerich. 2013. ’Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)’, Diabetes Care, 36: 2945-51.

Ross, R. 1999. ’Atherosclerosis--an inflammatory disease’, N. Engl. J. Med, 340: 115-26.

Russell-Jones, D., A. Vaag, O. Schmitz, B.K. Sethi, N. Lalic, S. Antic, M. Zdravkovic, G.M. Ravn, and R. Simo. 2009. ’Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial’, Diabetologia, 52: 2046-55.

Schwartz, E.A., J. Koska, M.P. Mullin, I. Syoufi, D.C. Schwenke, and P.D. Reaven. 2010. ’Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus’, Atherosclerosis, 212: 217-22.

Scirica, B. M., D. L. Bhatt, E. Braunwald, P. G. Steg, J. Davidson, B. Hirshberg, P. Ohman, R. Frederich, S. D. Wiviott, E. B. Hoffman, M. A. Cavender, J. A. Udell, N. R. Desai, O. Mosenzon, D. K. McGuire, K. K. Ray, L. A. Leiter, I. Raz, Savor-Timi Steering Committee, and Investigators. 2013. ’Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus’, N Engl J Med, 369: 1317-26.

Singh, S., H. Y. Chang, T. M. Richards, J. P. Weiner, J. M. Clark, and J. B. Segal. 2013. 'Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study', JAMA Intern Med, 173: 534-9.

Sjostrom, L., K. Narbro, C.D. Sjostrom, K. Karason, B. Larsson, H. Wedel, T. Lystig, M. Sullivan, C. Bouchard, B. Carlsson, C. Bengtsson, S. Dahlgren, A. Gummesson, P. Jacobson, J. Karlsson, A.K. Lindroos, H. Lonroth, I. Naslund, T. Olbers, K. Stenlof, J. Torgerson, G. Agren, and L.M. Carlsson. 2007. ’Effects of bariatric surgery on mortality in Swedish obese subjects’, N. Engl. J. Med, 357: 741-52.

Sokos, G.G., H. Bolukoglu, J. German, T. Hentosz, G.J. Magovern, Jr., T.D. Maher, D.A. Dean, S.H. Bailey, G. Marrone, D.H. Benckart, D. Elahi, and R.P. Shannon. 2007. ’Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting’, Am. J. Cardiol, 100: 824-29.

Sokos, G.G., L.A. Nikolaidis, S. Mankad, D. Elahi, and R.P. Shannon. 2006. ’Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure’, J. Card Fail, 12: 694-99.

Soranna D, Bosetti C, Casula M, Tragni E, Catapano AL, Vecchia CL, Merlino L, Corrao G. 2015. Incretin-based drugs and risk of acute pancreatitis: A nested-case control study within a healthcare database. Diabetes Res Clin Pract. 108(2):243-9.

Suarez EA, Koro CE, Christian JB, Spector AD, Araujo AB, Abraham S. Incretin-mimetic therapies and pancreatic disease: a review of observational data. Curr Med Res Opin. 2014 Dec;30(12):2471 81.

Suwaidi, J.A., S. Hamasaki, S.T. Higano, R.A. Nishimura, D.R. Holmes, Jr., and A. Lerman. 2000. ’Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction’, Circulation, 101: 948-54.

Tseng CH, Lee KY, Tseng FH. 2015. An updated review on cancer risk associated with incretin mimetics and enhancers. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 33(1):67-124.

Thomsen, R. W., L. Pedersen, N. Moller, J. Kahlert, H. Beck-Nielsen, and H. T. Sorensen. 2015. 'Incretin-based therapy and risk of acute pancreatitis: a nationwide population-based case-control study', Diabetes Care, 38: 1089-98.

Thrainsdottir, I., K. Malmberg, A. Olsson, M. Gutniak, and L. Ryden. 2004. ’Initial experience with GLP-1 treatment on metabolic control and myocardial function in patients with type 2 diabetes mellitus and heart failure’, Diab. Vasc. Dis. Res, 1: 40-43.

Timmers, L., J.P. Henriques, D.P. de Kleijn, J.H. Devries, H. Kemperman, P. Steendijk, C.W. Verlaan, M. Kerver, J.J. Piek, P.A. Doevendans, G. Pasterkamp, and I.E. Hoefer. 2009. ’Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury’, J. Am. Coll. Cardiol, 53: 501-10.

Trujillo, J. M., and W. Nuffer. 2014. ’GLP-1 receptor agonists for type 2 diabetes mellitus: recent developments and emerging agents’, Pharmacotherapy, 34: 1174-86.

Trujillo, J. M., W. Nuffer, and S. L. Ellis. 2015. ’GLP-1 receptor agonists: a review of head-to-head clinical studies’, Ther Adv Endocrinol Metab, 6: 19-28.
Turner, R.C., C.A. Cull, V. Frighi, and R.R. Holman. 1999. ’Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group’, JAMA, 281: 2005-12.

UKPDS. 1998. ’Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group’, Lancet, 352: 837-53.

Wadden, T. A., P. Hollander, S. Klein, K. Niswender, V. Woo, P. M. Hale, L. Aronne, and N. N. Investigators. 2013. ’Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study’, Int J Obes (Lond), 37: 1443-51.

Wang T, Wang F, Gou Z, Tang H, Li C, Shi L, Zhai S. 2015. Using real-world data to evaluate the association of incretin-based therapies with risk of acute pancreatitis: a meta-analysis of 1,324,515 patients from observational studies. Diabetes Obes Metab. 17(1):32-41.

Wenten, M., J. A. Gaebler, M. Hussein, E. M. Pelletier, D. B. Smith, P. Girase, R. A. Noel, D. K. Braun, and G. L. Bloomgren. 2012. 'Relative risk of acute pancreatitis in initiators of exenatide twice daily compared with other anti-diabetic medication: a follow-up study', Diabet Med, 29: 1412-8.

White, W. B., C. P. Cannon, S. R. Heller, S. E. Nissen, R. M. Bergenstal, G. L. Bakris, A. T. Perez, P. R. Fleck, C. R. Mehta, S. Kupfer, C. Wilson, W. C. Cushman, F. Zannad, and Examine Investigators. 2013. ’Alogliptin after acute coronary syndrome in patients with type 2 diabetes’, N Engl J Med, 369: 1327-35.

Williams-Herman, D., S.S. Engel, E. Round, J. Johnson, G.T. Golm, H. Guo, B.J. Musser, M.J. Davies, K.D. Kaufman, and B.J. Goldstein. 2010. ’Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes’, BMC. Endocr. Disord, 10: 7.

Vilsboll, T., M. Zdravkovic, T. Le-Thi, T. Krarup, O. Schmitz, J.P. Courreges, R. Verhoeven, I. Buganova, and S. Madsbad. 2007. ’Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes’, Diabetes Care, 30: 1608-10.

Wysham, C., T. Blevins, R. Arakaki, G. Colon, P. Garcia, C. Atisso, D. Kuhstoss, and M. Lakshmanan. 2014. ’Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1)’, Diabetes Care, 37: 2159-67.

Yamamoto, H., C.E. Lee, J.N. Marcus, T.D. Williams, J.M. Overton, M.E. Lopez, A.N. Hollenberg, L. Baggio, C.B. Saper, D.J. Drucker, and J.K. Elmquist. 2002. ’Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons’, J. Clin. Invest, 110: 43-52.

Zinman, B., B.J. Hoogwerf, Garcia S. Duran, D.R. Milton, J.M. Giaconia, D.D. Kim, M.E. Trautmann, and R.G. Brodows. 2007. ’The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial’, Ann. Intern. Med, 146: 477-85.
▼Detta läkemedel är föremål för utökad övervakning Trulicity 0,75 mg, 1,5 mg injektionsvätska, lösning i förfylld injektionspenna (dulaglutid). ATC-kod: A10BX14 Indikationer: Trulicity är avsett för vuxna med typ 2-diabetes mellitus för att förbättra glykemisk kontroll som: Monoterapi När behandling med enbart kost och motion inte ger tillräcklig glykemisk kontroll hos patienter för vilka behandling med metformin inte anses lämplig på grund av intolerans eller kontraindikationer. Tilläggsbehandling I kombination med andra glukossänkande läkemedel inklusive insulin, när dessa tillsammans med kost och motion inte ger tillräcklig glykemisk kontroll (se avsnitt 5.1 för data gällande olika kombinationsbehandlingar). Kontraindikationer: Överkänslighet mot den aktiva substansen eller mot något hjälpämne. Varning: Dulaglutid ska inte användas av patienter med typ 1-diabetes mellitus eller för behandling av diabetesketoacidos. Användning av GLP-1-receptoragonister kan sättas i samband med gastrointestinala biverkningar. Detta skall tas under övervägande då patienter med nedsatt njurfunktion behandlas eftersom dessa biverkningar, t ex illamående, kräkningar och/eller diarré, kan orsaka dehydrering vilket kan leda till en försämrad njurfunktion. Dulaglutid har inte studerats hos patienter med allvarlig gastrointestinal sjukdom, däribland allvarlig gastropares, och rekommenderas därför inte till dessa patienter. Användning av GLP-1- receptoragonister har satts i samband med en risk att utveckla akut pankreatit. Patienterna ska informeras om de karakteristiska symtomen på akut pankreatit. Om pankreatit misstänkts ska behandlingen med dulaglutid avbrytas. Om pankreatit bekräftas ska dulaglutid inte återinsättas. Utan andra tecken och symtom på akut pankreatit är förhöjda pankreasenzymer inte prediktivt för akut pankreatit. Patienter som får dulaglutid i kombination med en sulfonureid eller insulin kan löpa ökad risk för hypoglykemi. Risken för hypoglykemi kan minskas genom att dosen av sulfonureid eller insulin sänks. Datum för översyn av produktresumén: 2016-10-13 Läs bipacksedeln före användning. För ytterligare information och priser se www.fass.se. Rx, F Subventioneras för patienter som först har prövat metformin, sulfonureider eller insulin, eller när metformin eller sulfonureider inte är lämpliga. Subventioneras endast för patienter som inte behandlas i kombination med basinsulin. Eli Lilly Sweden AB, Box 721, 169 27 Solna. 08-737 88 00, www.lilly.se. Referens: Produktresumé (SPC) Trulicity (dulaglutid), www.fass.se | PP-DG-SE-0010
PP-DG-SE-0010
Top